Journal
TRENDS IN CELL BIOLOGY
Volume 12, Issue 4, Pages 178-184Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0962-8924(01)02246-2
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R01 GM053466] Funding Source: Medline
Ask authors/readers for more resources
Mitochondria adopt a variety of different shapes in eukaryotic cells, ranging from multiple, small compartments to elaborate tubular networks. The establishment and maintenance of different mitochondrial morphologies depends, in part, on the equilibrium between opposing fission and fusion events. Recent studies in yeast, flies, worms and mammalian cells indicate that three high-molecular-weight GTPases control mitochondrial membrane dynamics. One of these is a dynamin-related GTPase that acts on the outer mitochondrial membrane to regulate fission. Recently, genetic approaches in budding yeast have identified additional components of the fission machinery. These and other new findings suggest a common mechanism for membrane fission events that has been conserved and adapted during eukaryotic evolution.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available