Journal
JOURNAL OF IMMUNOLOGY
Volume 168, Issue 7, Pages 3266-3274Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.168.7.3266
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- NIAID NIH HHS [AI43440] Funding Source: Medline
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Human NK cells are likely to be important effectors of xenograft rejection. Expression of HI.A class I molecules by transfected porcine cells can protect them from human NK cell-mediated lysis; however, this strategy has the potential to augment the anti-graft response by recipient CD8(+) T cells recognizing foreign pig peptides presented by HLA. In this study we show that the introduction of a mutation (D227K) in the alpha(3) domain of HLA-Cw3 abrogates its recognition by CD8-dependent T cells but leaves intact its ability to function as an inhibitory ligand for NK cells. Such genetically modified molecules may have potential therapeutic applications in the prevention of delayed xenograft rejection and in the facilitation of allogeneic and xenogeneic bone marrow engraftment.
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