Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 30, Issue -, Pages 98-102Publisher
PORTLAND PRESS LTD
DOI: 10.1042/bst0300098
Keywords
COPD; emphysema; macrophage; macrophage elastase (MMP-12); neutrophil elastase
Categories
Ask authors/readers for more resources
Chronic obstructive pulmonary disease (COPD) is a major health problem worldwide, and we have little specific therapy to offer these patients. One potential strategy to limit loss of lung function in COPD would be to inhibit matrix-degrading proteinases. Several serine proteinases and matrix metalloproteinases are expressed in association with COPD in humans. Application of gene-targeted macrophage elastase and neutrophil elastase to a mouse model of cigarette-smoke-induced emphysema has uncovered roles for these proteinases in airspace enlargement, and has identified many interactions between these proteolytic systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available