Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 133, Issue 4, Pages 360-362Publisher
CONSULTANTS BUREAU
DOI: 10.1023/A:1016293904149
Keywords
cycloprolylglycine; content in mouse brain; anxiolytic activity; BALB/c; C57Bl/6
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Experiments on two mouse strains with opposite reactions to emotional stress showed selectivity of the anxiolytic effect of endogenous dipeptide cycloprolylglycine. In the open field test cycloprolylglycine (0.01-0.10 mg/kg intraperitoneally) dose-dependently (1.8-2.1-fold) increased motor activity of BALB/c mice with manifest fear reaction and had no effect on C57Bl/6 mice with active behavior. The content of endogenous cycloprolylglycine in mouse brain correlated with the type of emotional stress reaction: its content in the brain of C57Bl/6 mice 1.5 times surpassed that in BALB/c mice. It is concluded that cycloprolylglycine is involved in the endogenous regulation of fear reaction.
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