Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 12, Issue 2, Pages 142-148Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-437X(02)00279-4
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Funding
- NCI NIH HHS [CA78831] Funding Source: Medline
- NIGMS NIH HHS [GM55360] Funding Source: Medline
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Covalent modifications of the amino termini of the core histories in nucleosomes have important roles in gene regulation. Research in the past two years reveals these modifications to consist of phosphorylation, methylation and ubiquitination, in addition to the better-characterized acetylation. This multiplicity of modifications, and their occurrence in patterns and dependent sequences, argues persuasively for the existence of a histone code.
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