Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 42, Issue 1, Pages 57-64Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S1040-8428(02)00007-0
Keywords
copper; DNA-damage; cancer; toxicity; oxidative stress; free radicals
Categories
Ask authors/readers for more resources
Metal ions play an important role in biological systems, and without their catalytic presence in trace or ultratrace amounts many essential co-factors for many biochemical reactions would not take place. However, they become toxic to cells when their concentrations surpass certain optimal (natural) levels. Copper is an essential metal. Catalytic copper, because of its mobilization and redox activity, is believed to play a central role in the formation of reactive oxygen species (ROS), such as O-2(-) and OH radicals, that bind very fast to DNA, and produce damage by breaking the DNA strands or modifying the bases and/or deoxyribose leading to carcinogenesis. The chemistry and biochemistry of copper is briefly accounted together with its involvement in cancer and other diseases. (C) 2002 Published by Elsevier Science Ireland Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available