Journal
NEUROSCIENCE RESEARCH
Volume 42, Issue 4, Pages 279-285Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0168-0102(02)00007-X
Keywords
mental fatigue; central fatigue; creatine monohydrate; near infrared spectroscopy; oxygenated hemoglobin
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While the role of creatine in preventing muscle (peripheral) fatigue for high performance athletes is well understood, its biochemical role in prevention of mental (central) fatigue is not. Creatine is abundant in muscles and the brain and after phosphorylation used as an energy source for adenosine triphosphate synthesis. Using double-blind placebo-controlled paradigm. we demonstrated that dietary supplement of creatine (8 g/day for 5 days) reduces mental fatigue when subjects repeatedly perform a simple mathematical calculation. After taking the creatine supplement, task-evoked increase of cerebral oxygenated hemoglobin in the brains of subjects measured by near infrared spectroscopy was significantly reduced, which is compatible with increased oxygen utilization in the brain. (C) 2002 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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