Journal
DEVELOPMENTAL DYNAMICS
Volume 223, Issue 4, Pages 427-458Publisher
WILEY
DOI: 10.1002/dvdy.10073
Keywords
zebrafish; ear; otic placode; otic vesicle; statoacoustic ganglion; lateral line; hair cell; supporting cell; hearing; balance; auditory; vestibular; cell death; retinoic acid; BMP; Claudins; Dach; Delta-Notch; Eya1; FGF; Krml1; MyoVIIa; Nkx5.1; Pax2/5/8; Pou2; Raldh2; Sox10; Ugdh; Wnt; acerebellar; colourless; dog-eared; jekyll; mariner; mind bomb; monolith; neckless; no fin; no isthmus; one-eyed pinhead; spiel ohne grenzen; sputnik; valentino; van gogh; deafness
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Recent years have seen a renaissance of investigation into the mechanisms of inner ear development. Genetic analysis of zebrafish has contributed significantly to this endeavour, with several dramatic advances reported over the past year or two. Here, we review the major findings from recent work in zebrafish. Several cellular and molecular mechanisms have been elucidated, including the signaling pathways controlling induction of the otic placode, morphogenesis and patterning of the otic vesicle, and elaboration of functional attributes of inner ear. (C) 2002 Wiley-Liss, Inc.
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