Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 14, Issue 2, Pages 196-202Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0955-0674(02)00310-1
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Funding
- NIGMS NIH HHS [R01 GM027800-27] Funding Source: Medline
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Phosphatidylinositol 3-kinase lipid products and the Rho GTPases play a central role in transmitting information from chemotactic receptors to the effectors of cell polarity, and recent advances in the field have allowed us to understand these roles more clearly. Emergent properties of positive and negative regulation of these molecules may account for the establishment of cell polarity during chemotaxis for a wide range of cells from Dictyostelium to fibroblasts to neutrophils.
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