Journal
MAGNETIC RESONANCE IMAGING
Volume 20, Issue 3, Pages 277-284Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0730-725X(02)00491-5
Keywords
EPR imaging; in vivo; brain; BBB; nitroxide radicals
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In vivo temporal EPR imaging was conducted on the brain of rats that received one of two kinds of blood-brain barrier-permeable nitroxide radicals via the tail vein-one is a water-soluble 3-hydroxymethyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (hydroxymethyl-PROXYL); and the other is a non-water-soluble 3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (PCAM). From temporal EPR imaging data, temporal changes in the distribution of the nitroxide radical in the cerebral cortex, striatum, and hippocampus in the brain were investigated. It was found that the half-lives of the three parts in the brain of hydroxymethyl-PROXYL are longer and their EPR signal intensities are greater than those of PCAM. (C) 2002 Elsevier Science Inc. All rights reserved.
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