Journal
CELLULAR SIGNALLING
Volume 14, Issue 4, Pages 297-309Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0898-6568(01)00239-X
Keywords
GPCR; scaffolding protein; chaperone; GPCR dirner; G protein signalling; protein-protein interaction
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The mechanism by which G protein-coupled receptors (GPCRs) translate extracellular signals into cellular changes initially was envisioned as a simple linear model: activation of the receptor by agonist binding leads to dissociation of the heterotrimeric GTP-binding G protein into its alpha and betagamma subunits, both of which can activate or inhibit various downstream effector molecules. The plethora of recently described multidomain scaffolding proteins and accessory/chaperone molecules that interact with GPCR, including GPCR themselves as homo- or heterodimers, provides for diverse molecular mechanisms for ligand recognition, signalling specificity, and receptor trafficking, This review will summarize the recently described GPCR-interacting proteins and their individual functional roles, as understood, Implicit in the search for the functional relevance of these interactions is the expectation that enhancement or disruption of target cell-specific events could serve as highly selective therapeutic opportunities. (C) 2002 Elsevier Science Inc. All rights reserved.
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