4.7 Article

Novel steroidal vinyl fluorides as inhibitors of steroid C17(20) lyase

Journal

BIOORGANIC & MEDICINAL CHEMISTRY
Volume 10, Issue 4, Pages 929-934

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0968-0896(01)00354-6

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20-Fluoro-17(20)-prognenolone derivatives were designed as enol mimics of pregnenolone. All of the targeted, novel fluoroolefins were potent inhibitors of C-17(20) lyase. (C) 2002 Elsevier Science Ltd. All rights reserved.

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