Journal
ORGANIC LETTERS
Volume 4, Issue 7, Pages 1095-1098Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol017275j
Keywords
-
Categories
Funding
- NCI NIH HHS [CA52995] Funding Source: Medline
- NIGMS NIH HHS [GM63554] Funding Source: Medline
Ask authors/readers for more resources
[GRAPHICS] Bioassay-guided investigation of the extract from a Lyngbya majuscula/Schizothrix sp. assemblage of marine cyanobacteria led to the discovery of somocystinamide A (1), an extraordinary disulfide dimer of mixed PKS/NRPS biosynthetic origin. Somocystinamide A (1) was highly acid-sensitive, rapidly and completely converting to a characterizable derivative (2). Compound 1 exhibits significant cytotoxicity against mouse neuro-2a neuroblastoma cells (IC50 = 1.4 mug/mL), whereas 2 has no activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available