A study of the functional group compatibility of sulfoximination methods

The sulfoximination of a range of sulfoxides possessing functionalised side-chains using mesitylene sulfonyl hydroxyl-amine or iminoiodane reagents is discussed. The use of iminoiodane reagents possessing removable protecting groups (p-nosyl and Ses) is reported along with conditions for the deprotection of the sulfoximine adducts. (C) 2002 Elsevier Science Ltd. All rights reserved.