Journal
FEBS LETTERS
Volume 516, Issue 1-3, Pages 106-108Publisher
WILEY
DOI: 10.1016/S0014-5793(02)02511-5
Keywords
membrane protein; signal peptide; signal peptidase; tail-anchor
Funding
- NIGMS NIH HHS [GM 26494] Funding Source: Medline
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Tail-anchored proteins are post-translationally targeted and inserted into the endoplasmic reticulum membrane. They do not use the co-translational sign at-recognition particle (SRP)-dependent pathway, but rather utilize an ill-defined, ATP-dependent mechanism. Here, we show that a tail-anchored protein can be cleaved by signal peptidase and that the sequence requirements for efficient cleavage seem to be the same as for cleavage of co-translationally targeted SRP-dependent proteins. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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