Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 440, Issue 2-3, Pages 213-221Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(02)01430-9
Keywords
ACRP30 (adipocyte complement-related protein of 30 kDa); AdipoQ; adiponectin; obesity; diabetes; insulin resistance; lipid metabolism; glucose metabolism
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Funding
- NIDDK NIH HHS [R37DK47618] Funding Source: Medline
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Adipocyte complement-related protein of 30 kDa (ACRP30) is a secreted serum protein expressed exclusively in differentiated adipocytes. Recent studies have indicated that its expression and serum levels are reduced in humans and animals with obesity and insulin resistance. Metabolic studies have demonstrated a role for ACRP30 in the regulation of glucose and lipid homeostasis. This review will describe the current literature on the biochemistry of ACRP30 and its physiological functions. We will also discuss issues that are relevant to the directions of future research. (C) 2002 Elsevier Science B.V. All rights reserved.
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