Journal
BRAIN RESEARCH
Volume 933, Issue 1, Pages 81-84Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(02)02306-5
Keywords
adrenalectomy; apoptotic cell death; dentate gyrus; neuronal nitric oxide synthase
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Recent studies have shown that the expression of neuronal nitric oxide synthase (NOS) mRNA is increased after adrenalectomy (ADX). However, the role of increased NO production after ADX in the dentate gyrus is unknown. In this study, the relationship between NO inhibition and apoptosis in the dentate gyrus after ADX was examined. 7-Nitroindazole (7-NI; 30 mg/kg, i.p.), a selective inhibitor of neuronal NOS, was injected 1 day before ADX and subsequently once every 24 h. Then 4 days after ADX, dentate granule cell death was evaluated using silver impregnation and Nissl staining methods. Inhibition of neuronal NOS by 7-NI increased the number of dying granule cells similar to4-fold in the dentate gyrus of the ADX rats, compared to vehicle-injected ADX controls. These results suggest that increased NO production after ADX may play an endogenous neuroprotective role in the dentate gyrus. (C) 2002 Elsevier Science B.V. All rights reserved.
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