Journal
NEUROREPORT
Volume 13, Issue 5, Pages 611-615Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200204160-00015
Keywords
Alzheimer's disease; apolipoproteins; cerebrospinal fluid; mass spectrometry; proteomics; two-dimensional electrophoresis
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By comparing the CSF proteome between Alzheimer disease (AD) patients and controls it may be possible to identify proteins that play a role in the disease process and thus to study the pathogenesis of AD. We used mini-gel technology in a two-dimensional electrophoresis procedure, sensitive SYPRO Ruby staining and mass spectrometry for clinical screening of disease-influenced CSF proteins in 15 AD patients and 12 controls. The levels of six proteins and their isoforms, including proapolipoprotein, apolipoprotein E, beta-2 microglobulin, retinol-binding protein, transthyretin, and ubiquitin, were significantly altered in CSF of AD patients. The most prominently altered proteins were the apolipoproteins, especially proapolipoprotein. NeuroReport 13:611-615 (C) 2002 Lippincott Williams Wilkins.
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