Calix[4]arenes linked to multiple bidentate N-donors: Potential ligands for synthetic modeling of multinuclear metalloenzymes

[GRAPHICS] A series of calix[4]arenes incorporating three or four bidentate diamines or pyridylamines attached at the upper rim were synthesized via practical protocols. Proof of structure was obtained in one instance by X-ray crystallography. These molecules are designed for general use as ligands for the preparation of multinuclear active site models of metalloenzymes.