Journal
JOURNAL OF COMPARATIVE NEUROLOGY
Volume 446, Issue 1, Pages 1-10Publisher
WILEY
DOI: 10.1002/cne.10177
Keywords
apoptosis; natural cell death; development
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Funding
- NEI NIH HHS [R01 EY12654] Funding Source: Medline
- Telethon [E.0833] Funding Source: Medline
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Naturally occurring cell death is believed to play a major role during the development of the nervous system in the establishment of neuronal architecture. Here we study the effects of cell death inhibition by using a transgenic mouse in which the powerful antiapototic gene bcl-2 is expressed in neurons. The retina of this mouse reveals that the general neuronal plan has been maintained. However, bcl-2 overexpression leads to altered frequencies of the major cell types in the retina. Thus, it is possible to estimate cell-type-specific rates of apoptosis by observing the increases in numbers of cells in the bcl-2-overexpressing transgenic mouse. J. Comp. Neurol. 446:1-10, 2002. (C) 2002 Wiley-Liss, Inc.
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