Journal
NEUROLOGY
Volume 58, Issue 8, Pages 1277-1279Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.58.8.1277
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Levels of the potent pro-inflammatory prostaglandin E-2 (PGE(2)) are elevated in postmortem spinal cords from patients with ALS, and inhibition of a key PGE(2)-synthesizing enzyme, cylcooxygenase-2, is neuroprotective in an in vitro model of ALS. The authors report that 82% of the patients with ALS studied had 2 to 10 times higher PGE(2) levels in CSF compared with normal control subjects. That affected areas of the CNS are inflamed in ALS supports this. CSF PGE(2) measurement may be useful in monitoring treatment for ALS.
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