Journal
TETRAHEDRON
Volume 58, Issue 18, Pages 3513-3524Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(02)00310-1
Keywords
dihydrodipyridopyrazines; formylation; nitration
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Unprecedented dihydrodipyridopyrazines were easily obtained by hetarynic dimerization of 2-alkylamino-3-halogenopyridines in the presence of the complex base NaNH2-tBuONa. Derivatizations of the new heterocycles are described. The anticancer activity of these compounds is also mentioned. (C) 2002 Elsevier Science Ltd. All rights reserved.
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