Journal
VETERINARY PARASITOLOGY
Volume 105, Issue 2, Pages 111-118Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0304-4017(01)00609-4
Keywords
pathogenicity; genetics; trypanosoma congolense; inbred Balb/c mice
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Inbred Balb/c mice were infected with three clones of Trypanosoma congolense (Sam.28.1, Dind.3.1 and K60.1A) corresponding, respectively, to the three genetically distinct types (savannah, forest and kilifi) defined within this species, for the purpose of comparing their pathogenicity for a better understanding of the epidemiology of African trypanosomosis. Another clone of savannah type, IL 3000, was also tested simultaneously to study a probable strain variation. Both the clones of savannah type were found of extreme virulence with loss of appetite, rough hair, rapid respiration, lethargy, and all mice died within a week. Parasitaemias evolved rapidly to the first peak by day 3-5 post-inoculation without any remission and the course of disease was correlated positively with the prepatent period. The clones of the forest type and the kilifi type were of low virulence with chronic infection and symptoms progressively less patent throughout the infection; only one mouse died in each experimental group. (C) 2002 Elsevier Science B.V. All rights reserved.
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