Journal
PLANTA MEDICA
Volume 68, Issue 5, Pages 457-459Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2002-32070
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The bioassay-directed isolation of Terminalia chebula fruits afforded four human immunodeficiency virus type 1 (HIV-1) integrase inhibitors, gallic acid (1) and three galloyl glucoses (2-4). In addition, four flavonol glycoside gallates (5-8) from Euphorbia pekinensis containing the galloyl moiety also showed the inhibitory activity at a level comparable to those of 2-4. By comparison with the activities of the compounds not bearing this moiety, it is proposed that the galloyl moiety plays a major role for inhibition against the 3'-processing of HIV-1 integrase of these compounds.
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