Journal
DEVELOPMENTAL CELL
Volume 2, Issue 5, Pages 655-666Publisher
CELL PRESS
DOI: 10.1016/S1534-5807(02)00147-8
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Funding
- NCRR NIH HHS [1S10 RR 09145-01] Funding Source: Medline
- NEI NIH HHS [EY 13256] Funding Source: Medline
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Planar cell polarity is established in the Drosophila eye through distinct fate specification of photoreceptors R3 and R4 by a two-tiered mechanism employing Fz and Notch signaling: Fz signaling specifies R3 and induces DI to activate Notch in R4. We show that the atypical cadherin Flamingo (Fmi) plays critical, but distinct, roles in both R3 and R4. Fmi is first enriched at equatorial cell borders of R3/R4, positively interacting with Fz/Dsh. Subsequently, Fmi is upregulated in R4 by Notch and functions to downregulate DI expression by antagonizing Fz signaling. This in turn amplifies and enforces the initial Fz-signaling bias in the R3/R4 pair. Our results reveal differences in the planar cell polarity genetic circuitry between the eye and the wing.
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