Journal
CURRENT OPINION IN CARDIOLOGY
Volume 17, Issue 3, Pages 218-221Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001573-200205000-00002
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Recent advances in molecular genetics of arrhythmogenic right ventricular cardiomyopathy (ARVD) are reviewed. In particular, the finding of mutations in the gene coding for cardiac ryanodine receptor (hRYR2), both in patients affected with ARVD2 and in patients affected with catecholaminergic ventricular arrhythmias or with familial ventricular tachyarrhythmia, is discussed. Novel data support the hypothesis that apoptosis may be a key step in molecular pathogenesis of ARVDs. A series of studies on drugs with apparent protective effect against apoptosis in myocardial cells might open new perspectives in the therapeutic approach. Curr Opin Cardiol 2002, 17:218-221 (C) 2002 Lippincott Williams Wilkins, Inc.
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