Journal
CURRENT OPINION IN RHEUMATOLOGY
Volume 14, Issue 3, Pages 244-249Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00002281-200205000-00009
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Funding
- NIAID NIH HHS [AI36529, AI48120] Funding Source: Medline
- NIAMS NIH HHS [F32AR47759] Funding Source: Medline
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Perhaps one of the most elusive areas of study in autoimmunity has been identifying the self-antigens that initially trigger the development of autoimmune responses. Recent work in this area has demonstrated that a number of biochemical modifications that arise in proteins after their translation induce autoimmune responses to otherwise ignored self-proteins. This article will describe those autoimmune diseases in which posttranslational modifications may play a role in initiation of disease, as well as identify how these modifications arise and contribute to the breakdown of immune tolerance. Lastly, we will address how posttranslational modifications in self-antigens affect current diagnostic techniques and the development of immunotherapies for autoimmune diseases. (C) 2002 Lippincott Williams Wilkins, Inc.
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