Journal
AURIS NASUS LARYNX
Volume 40, Issue 2, Pages 207-210Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.anl.2012.07.014
Keywords
Laryngeal cancer; Infection; Complication; Radiation failure
Categories
Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [20592028]
- Grants-in-Aid for Scientific Research [20592028, 21249065, 24592608] Funding Source: KAKEN
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Objective: A history of radiation therapy is known to be a major risk factor promoting post-surgical complications. By comparing the clinical outcomes of supracricoid laryngectomy with cricohyoidoepiglottopexy (SCL-CHEP) in irradiated and non-irradiated patients, we investigated the usefulness of salvage SCL-CHEP. Methods: 73 patients who received SCL-CHEP between 1997 and 2010 (30 had received radiation therapy preoperatively and 43 had not). Staging error, wound infection, accuracy of surgical margin determination, acquired laryngeal function, and prognosis were compared between the two groups. Results: Staging error occurred in 6/30 (20%) irradiated and 14/43 (33%) non-irradiated patients. An intraoperative margin study demonstrated a dysplastic or positive margin in 15/30 (50%) irradiated and 13/43 (30%) non-irradiated patients. Wound infection developed in 12/30(40%) irradiated and 7/43 (16%) non-irradiated patients (P < 0.05). Delayed wound infection was identified in four patients with a radiation dose over 65 Gy. Swallowing function (ability to eat in public) was acquired in 28/30 (93%) irradiated and 39/43 (91%) non-irradiated patients. Five-year larynx preservation rates were 94% in irradiated and 91% in non-irradiated patients. Five-year overall survival rates were 81% in irradiated and 87% in non-irradiated patients. Conclusions: Risk of infection was significantly higher in irradiated patients; delayed infection should be appropriately managed. Functional and oncological results were stable regardless of radiation history. We encourage head and neck surgeons to take reasonable risks in performing salvage SCL-CHEP. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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