Journal
MICROBIAL PATHOGENESIS
Volume 32, Issue 5, Pages 249-254Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1006/mpat.2002.0503
Keywords
Burkholderia cepacia complex; Burkholderia vietnamiensis; hemolysin; phospholipase; general secretion pathway; amoebae
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Members of the Burkholderia cepacia complex can secrete proteases, lipases, and hemolysins. We report in this study the identification of a general secretory pathway present in a B. vietnamiensis (formerly genomovar V) clinical isolate, which is required for the efficient secretion of phospholipase C and hemolysin activities. Southern blot hybridization experiments revealed that this general secretion pathway is highly conserved among the different genomovars of the B. cepacia complex and is homologous to a similar system described in B. pseudomallei. We also show that this pathway appears not to be necessary for intracellular survival of B. vietnamiensis within Acanthamoeba polyphaga. (C) 2002 Elsevier Science Ltd. All rights reserved.
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