Journal
DEVELOPMENTAL CELL
Volume 2, Issue 5, Pages 579-591Publisher
CELL PRESS
DOI: 10.1016/S1534-5807(02)00146-6
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Funding
- NCI NIH HHS [P30 CA 46934] Funding Source: Medline
- NIGMS NIH HHS [GM 47869] Funding Source: Medline
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The in vivo functions of ARF-like members of the Ras superfamily of GTPases are relatively unexplored. Here we describe the analysis of C. elegans evl-20 gene that encodes a functional homolog of human ARL2. Elimination of evl-20 function results in abnormal vulval, gonad, and male tail development and disrupts embryonic proliferation, hypodermal enclosure, and elongation. Loss of evl-20 function causes specific defects in the microtubule cytoskeleton, which is the likely molecular basis for the observed defects. EVL-20 is closely associated with both the cell cortex and astral microtubules, suggesting that it may directly interact with microtubule structures at those locations. Our data indicate that EVL-20 functions in the cytoplasm and at the plasma membrane to regulate cytoskeletal dynamics during cytokinesis and morphogenesis.
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