Journal
NATURE NEUROSCIENCE
Volume 5, Issue 5, Pages 446-451Publisher
NATURE AMERICA INC
DOI: 10.1038/nn832
Keywords
-
Categories
Funding
- NIDA NIH HHS [DA05923] Funding Source: Medline
- NINDS NIH HHS [NS30470] Funding Source: Medline
Ask authors/readers for more resources
The striatum functions critically in movement control and habit formation. The development and function of cortical input to the striatum are thought to be regulated by activity-dependent plasticity of corticostriatal glutamatergic synapses. Here we show that the induction of a form of striatal synaptic plasticity, long-term depression (LTD), is dependent on activation of the CB1 cannabinoid receptor. LTD was facilitated by blocking cellular endocannabinoid uptake, and postsynaptic loading of anandamide (AEA) produced presynaptic depression. The endocannabinoid necessary for striatal LTD is thus likely to be released postsynaptically as a retrograde messenger. These findings demonstrate a new role for endocannabinoids in the induction of long-term synaptic plasticity in a circuit necessary for habit formation and motor control.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available