Journal
CELL CALCIUM
Volume 31, Issue 5, Pages 245-251Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0143-4160(02)00053-2
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Funding
- NIA NIH HHS [AG00836, AG00919] Funding Source: Medline
- NINDS NIH HHS [NS30884] Funding Source: Medline
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New fluorescent indicators with nanomolar to micromolar affinities for Zn2+ have been synthesized in wavelengths from UV to the far red. The UV light-excited indicators are ratiometric. The visible wavelength indicators are non-ratiometric and exhibit large and pH-independent fluorescence increases with increasing zinc concentrations, with little to no sensitivity to physiologically relevant Ca2+ concentrations. Experiments in neuronal and non-neuronal cell cultures show the new indicators to retain their sensitivity to and selectivity for zinc after conversion to cell-permeable forms. (C) 2002 Elsevier Science Ltd. All rights reserved.
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