Journal
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
Volume 28, Issue 2, Pages 343-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/S0889-857X(01)00013-8
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In fibromyalgia an NMDA-receptor antagonist (ketamine) has been used for diagnosis of central sensitization of the nociceptive central nervous system in patients with fibromyalgia. The combination of another NMDA-receptor antagonist (dextromethorphan) and a weak opioid (tramadol) has been studied with respect to pain relief. A subset of patients may benefit from this treatment.
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