Journal
BONE MARROW TRANSPLANTATION
Volume 29, Issue 10, Pages 867-869Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bmt.1703552
Keywords
reduced-intensity HSCT; Epstein-Barr; post-transplant lymphoproliferative disorder; CAMPATH
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Post-transplant lymphoproliferative disorders (PTLD) are a well recognised complication of conventional haemopoietic stem cell transplantation (HSCT). Reduced intensity HSCT involves intensive immunosuppression to permit engraftment. Thirty reduced intensity transplants with the FBC (fludarabine 150 mg/m(2), busulphan 8 mg/m(2), CAMPATH-1H 100 mg) protocol have been performed at our centre, with one confirmed EBV-positive PTLD. The female recipient developed a perforated viscus day +191 following HSCT from a volunteer unrelated male donor. A large caecal mass and a retroperitoneal abscess were excised, revealing an EBV-positive diffuse large B cell lymphoma confirmed by FISH to be of donor origin. More experience is required before the risk of PTLD in this setting can be assessed.
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