Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 32, Issue 9, Pages 841-859Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0891-5849(02)00786-4
Keywords
nitric oxide; nitrogen dioxide; carbonate radical anion; oxidative stress; nitrosoactive stress; superoxide anion; peroxynitrite; reactive nitrogen species; free radicals
Ask authors/readers for more resources
Nitrogen dioxide and carbonate radical anion have received sporadic attention thus far from biological investigators. However, accumulating data on the biochemical reactions of nitric oxide and its derived oxidants suggest that these radicals may play a role in various pathophysiological processes. These potential roles are also indicated by recent studies on the high efficiency of urate and nitroxides in protecting cells and whole animals against the injury associated with conditions of excessive nitric oxide production. The high protective effects of these antioxidants are incompletely defined at the mechanistic level but some of them can be explained by their efficiency in scavenging peroxynitrite-derived radicals, particularly nitrogen dioxide and carbonate radical anion. In this review, we provide a framework for this hypothesis and discuss the potential sources and properties of these radicals that are likely to become increasingly recognized as important mediators of biological processes. (C) 2002 Elsevier Science Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available