Journal
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
Volume 28, Issue 3, Pages 257-261Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1023/A:1015720707433
Keywords
asymmetric hydroxylation; cholesterol; oxysterols; steroids
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The syntheses of (24S)-24,25-epoxycholesterol, (24S)-hydroxycholesterol, and 24-ketocholesterol are described. The compounds belong to oxysterols, which can be considered to be the modulators of cholesterol metabolism. The asymmetric hydroxylation of desmosterol acetate according to Sharpless was used as the key reaction in the stereoselective introduction of functionality in position 24.
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