Journal
BIOCONJUGATE CHEMISTRY
Volume 13, Issue 3, Pages 605-610Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bc0155723
Keywords
-
Categories
Funding
- NCI NIH HHS [CA79443, CA88365, CO97065, CA86355] Funding Source: Medline
Ask authors/readers for more resources
Recently, near-infrared (NIR) fluorescence light has been applied to image various biological events in vivo, because it penetrates tissue more efficiently than light in the visible spectrum. Compounds exhibiting fluorescent properties in the NIR range are key elements for this upcoming optical imaging technology. In this paper, we report the synthesis of four new, water-soluble NIR cyanine fluorochromes which have superior chemical stability and optical properties. Each fluorochrome was designed with a monoreactive carboxyl group for labeling purposes. When multiple fluorochromes were attached to a single macromolecule, fluorescence quenching was observed. On the basis of this property, a novel autoquenched enzyme sensitive NIR fluorescence probe was prepared.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available