Journal
JOURNAL OF IMMUNOLOGY
Volume 168, Issue 9, Pages 4643-4649Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.168.9.4643
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Funding
- NIAID NIH HHS [N01-AI55270] Funding Source: Medline
- PHS HHS [A132573] Funding Source: Medline
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The role of CD40/CD154 interaction during infection has primarily focused on pathogens that drive inflammatory Th1 responses. In this study, we show that CD40/CD154 interaction is a fundamental requirement for Th2 response development to the parasitic helminth Schistosoma mansoni. Compared with infected wild-type mice, greatly reduced levels of Th2-associated cytokines were measured both in vitro and in vivo, and no IgE or IgG1 was detected in infected CD154(-/-) mice. In the absence of an overt Th2 response, no exaggerated Th1 response was mounted by CD154(-/-) mice. Infected CD154(-/-) mice suffered severe morbidity and mortality, even though parasitemias in wild-type and CD154(-/-) mice did not differ significantly. These data indicate that CD40/CD154 interaction is required to allow development of a Th2-dominated immune response to S. mansoni and support the view that failure to develop such a response can have fatal consequences.
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