Journal
MOLECULAR AND CELLULAR BIOLOGY
Volume 22, Issue 9, Pages 3066-3077Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.22.9.3066-3077.2002
Keywords
-
Categories
Ask authors/readers for more resources
Many growth factors and hormones modulate the reproductive status in mammals. Among these, insulin and insulin-like growth factor I (IGF-I) regulate the development of gonadal tissues. SH2-B has been shown to interact with insulin and IGF-I receptors, although the role of SH2-B in these signals has not been clarified. To investigate the role of SH2-B, we generated mice with a targeted disruption of the SH2-B gene. Both male and female SH2-B-/- mice showed slight retardation in growth and impaired fertility. Female knockout mice possess small, anovulatory ovaries with reduced numbers of follicles and male SH2-B-/- mice have small testes with a reduced number of sperm. SH2-B-/- cumulus cells do not respond to either follicle-stimulating hormone or IGF-I. These data suggest that SH2-B plays a critical role in the IGF-1-mediated reproductive pathway in mice.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available