Journal
GLIA
Volume 38, Issue 3, Pages 268-272Publisher
WILEY
DOI: 10.1002/glia.10068
Keywords
inwardly rectifying K+ currents; voltage-gated Na+ currents; glutamate uptake
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The electrophysiology of murine Muller cells, and of their precursors, during postnatal development was investigated by using the whole-cell patch-clamp technique. Membrane potential, membrane capacitance, and expression of voltage-gated Na+ currents increased during the first 3 postnatal weeks. During the same period, the membrane resistance decreased due to an upregulation of both inward and outward K+ currents. Glutamate transporter-mediated currents increased during the first postnatal weeks, as well. In Muller (precursor) cells from rabbits, these transporter currents already achieved adult levels at postnatal day 6, the earliest stage studied. Together with the developmental time course of K+ currents, this indicates a delay in the maturation of murine Muller cells, as compared with cells from rabbit. (C) 2002 Wiley-Liss, Inc.
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