Journal
MOLECULAR CELL
Volume 9, Issue 5, Pages 931-943Publisher
CELL PRESS
DOI: 10.1016/S1097-2765(02)00540-3
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Key events in mitosis such as sister chromatid separation and subsequent inactivation of cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events are mediated by the anaphase-promoting complex (APC), a cell cycle-regulated ubiquitin ligase that assembles multiubiquitin chains on regulatory proteins such as securin and cyclins and thereby targets them for destruction by the 26S proteasome.
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