Silver-nanoparticle-incorporated composite nanofibers for potential wound-dressing applications

The aim of this study was to develop stable and porous poly(ethylene oxide) (PEO)-polycaprolactone blended and silver nanoparticle (Ag NP) incorporated composite nanofiber scaffolds as antibacterial wound dressings. A facile approach for the in situ synthesis of Ag NPs was explored. In this synthesis method, N,N-dimethylformamide (DMF) was used as a solvent; it also acted as reducing agent for Ag NP formation. The stabilization of Ag NPs in the fibers was accomplished by PEO, which in turn acted as a reducing agent along with DMF. The successful synthesis of crystalline Ag NPs was confirmed by various characterization techniques. Thermogravimetric analysis, wettability, and surface roughness analysis of the nanofibers were done to examine the suitability of the scaffold for wound dressing. The as-synthesized composite nanofibers possessed good roughness, wettability, and antibacterial potential against recombinant green fluorescent proteins expressing antibiotic-resistant Escherichia coli. Thus, the nanofiber scaffold fabricated by this approach could serve as an ideal wound dressing. (C) 2015 Wiley Periodicals, Inc.