Journal
BIOLOGY OF REPRODUCTION
Volume 66, Issue 5, Pages 1267-1273Publisher
SOC STUDY REPRODUCTION
DOI: 10.1095/biolreprod66.5.1267
Keywords
anterior pituitary; estrogen receptor; growth hormone; growth hormone-releasing hormone; hypothalamic hormones; hypothalamus; luteinizing hormone
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Evidence suggests that estrogen modulates growth hormone (GH) release and that GH plays an important role in follicular and ovulatory processes. How estradiol affects GH secretion is unclear. Having verified that there is a coincident surge of CH at the time of the preovulatory LH surge, immunocytochemical studies incorporating high-temperature antigen retrieval were used to determine whether GH-releasing hormone (GHRH) neurons, somatotropes, or both, expressed estrogen receptor a (ER), in the ewe. Although GHRH neurons were surrounded by many ER cells, they did not express immunocytochemically detectable ERs. In contrast to gonadotropes, in which the majority expressed ERs, few somatotropes were estrogen receptive. These data suggest that estrogen does not act directly on GHRH neurons to influence GH secretion, and any direct effect on pituitary GH release, through the ERalpha, may be small.
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