Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 3, Issue 5, Pages 364-375Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm804
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Over the past few years, several new 3'-5' exonucleases have been identified. In vitro studies of these enzymes have uncovered much about their potential functions in vivo, and certain organisms with a defect in 3'-5' exonucleases have an increased susceptibility to cancer, especially under conditions of stress. Here, we look at not only the newly discovered enzymes, but also at the roles of other 3'-5' exonucleases in the quality control of DNA synthesis, where they act as proofreading exonucleases for DNA polymerases during DNA replication, repair and recombination.
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