Journal
NATURE CELL BIOLOGY
Volume 4, Issue 5, Pages E131-E136Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb0502-e131
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The transcription factor AP-1 ( activator protein-1) is involved in cellular proliferation, transformation and death. Using mice and cells lacking AP-1 components, the target-genes and molecular mechanisms mediating these processes were recently identified. Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators. Mostly, c-Jun is a positive regulator of cell proliferation, whereas JunB has the converse effect. The intricate relationships between the different Jun proteins, their activities and the mechanisms that mediate them will be discussed.
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