Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 126, Issue 1-2, Pages 25-36Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(02)00045-0
Keywords
biepisodic EAE; experimental autoimmune encephalomyelitis; MHC; susceptibility to autoimmunity; Vbeta usage; Wistar Kyoto rat
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Funding
- NIAID NIH HHS [AI-28419] Funding Source: Medline
- NIAMS NIH HHS [AR45799] Funding Source: Medline
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Here, we demonstrate that the Wistar Kyoto (WKY/NHsd) rat, which bears the same RT1(1) haplotype as the experimental autoimmune encephalomyelitis (EAE)-susceptible Lewis rat strain, is highly resistant to myelin basic protein (MBP)-induced EAE. No differences between Lewis and WKY strains were found in T cell proliferative specificity or the use of Vbeta8.2 T cell receptors in response to MBP. A Th2 cytokine bias correlated with WKY's EAE resistance. MBP challenge of WKY-into-Lewis adoptive transfer recipients produced a novel biepisodic EAE. The WKY strain should be useful in studies of many tissue-specific autoimmune diseases to which the Lewis rat is susceptible. (C) 2002 Elsevier Science B.V. All rights reserved.
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