Journal
PEPTIDES
Volume 23, Issue 5, Pages 927-934Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0196-9781(02)00003-7
Keywords
neuropeptide Y receptors; autonomic nervous system; blood vessels; RT-PCR
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mRNA encoding the human NPY Y-1 and NPY Y-2 receptors were detected in cerebral, meningeal, and coronary arteries using reverse transcriptase-polymerase chain reaction (RT-PCR). In addition, the trigeminal and superior cervical ganglia were positive for both receptors. In some arteries and in SK-N-MC cells only mRNA encoding the NPY Y-1 was detected. Besides the expected NPY Y-1 PCR products, an additional 97 bp longer amplicon originating from an alternative splicing event was found in most tissues studied. Antibodies directed against the NPY Y-1 receptor revealed immunostaining mainly in the smooth muscle layer of blood vessels whereas antibodies against the NPY Y-2 receptor showed immunostaining in nerve cell bodies. (C) 2002 Elsevier Science Inc. All rights reserved.
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