Journal
PROTEIN ENGINEERING
Volume 15, Issue 5, Pages 359-363Publisher
OXFORD UNIV PRESS
DOI: 10.1093/protein/15.5.359
Keywords
hydrogen-bonding criteria; protein tertiary structure; side chain-side chain packing
Ask authors/readers for more resources
Empirical criteria for identification of hydrogen bonds were analyzed to produce a set of geometrically consistent criteria. For a data set of 30 structures, application of a set of purely geometrical criteria, along with exclusion of abnormal backbone conformations, also excluded a common interaction of Ser/Thr side chains with Asp/Glu side chains ([ST]/[DE] pairs). These interactions were termed `bifurcated hydrogen bonds/', which implies delocalization of a positively charged hydrogen of hydroxyl between the two acceptor atoms of the carboxylic group. These `bifurcated/' interactions are among the most common packing patterns for [ST]/[DE] pairs of side chains. Therefore, the identification of hydrogen bonds cannot be based on geometrical criteria only and requires introduction of some physico-chemical criteria.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available