Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 650, Issue 1-2, Pages 1-24Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/S0022-328X(02)01150-6
Keywords
allylic alcohols; carbonyl compounds; isomerisation; transition metals; homogeneous catalysis
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Isomerisation of allylic alcohols forms an elegant shortcut to carbonyl compounds in a completely atom-economical process that offers several useful applications in natural-product synthesis and in bulk chemical processes. This review focuses on the heart of isomerisation catalysis: the catalyst. Combinations of transition metals (from Group 4 to 10), ligands and reaction conditions are compared with respect to yield, turnovers. rate and selectivity. A selected number of clever solutions to synthetic problems are highlighted, such as the synthesis of enols and enolates, chiral carbonyl compounds and silyl substituted ketones. Furthermore, a general overview of the mechanisms proposed for the isomerisation of allylic alcohols is given while some catalyst systems are singled out to discuss mechanistic research. (C) 2002 Published by Elsevier Science B.V.
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