Journal
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
Volume 132, Issue 1, Pages 147-152Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S1095-6433(01)00541-4
Keywords
phosphorescence oxygen; maximum entropy method; lifetime distributions; luminescence quenching; oxygen distributions; heterogeneous objects; phosphorescence instrumentation
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Phosphorescence lifetime of phosphors dissolved in biological fluids is dependent on the local oxygen concentration. When phosphor is added to the blood in vivo there is a distribution of lifetimes due to the distribution of oxygen concentrations in the blood of the sampled tissue volume. The distribution of oxygen can be assessed non-invasively and in practically real-time using frequency domain time-resolved phosphorometry. Here we describe a multi-frequency system for measurements of oxygen distributions in tissue in vivo. (C) 2002 Elsevier Science Inc. All rights reserved.
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